A single cell-based system to investigate mechanisms of neurodegeneration

Montserrat Arrasate Iragui, Programa en Neurociencias, Centro de Investigación Médica Aplicada, Universidad de Navarra

Resumen: Using a methodology based on automated microscopy and longitudinal survival analysis we study molecular mechanisms of neurodegeneration. Specifically, I will introduce a neuronal model of alpha-synuclein in which we have determined how alpha-synuclein expression, stability, pathological mutations or post-translational modifications (PS129, N-terminal acetylation) influence neuronal death. Additionally, I will show an assay that we have set up to score for cell-autonomous and non-cell-autonomous alpha-synuclein toxicity.

Bio:B.Sc. Biochemistry and Molecular Biology, University of Navarra (Spain), Ph.D. Sciences, Centro de Biología Molecular “Severo Ochoa”- CSIC, Spain, Thesis advisor: Dr. Jesús Avila. Role of tau protein in neurodegeneration. Postdoctoral Training and Research Scientist at Gladstone Institute of Neurological Disease, University of California, San Francisco. Advisor: Dr. Steve Finkbeiner. Project: Molecular mechanisms of neurodegeneration in Huntington’s disease. Current position: Investigator, Center for Applied Medical Research (CIMA) and Assistant Professor, Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra.

Fecha y hora: viernes 22 de noviembre, 12:30 h.

Lugar: Seminario IV