Seminario de Investigación: "Function and Anatomy of Long-Range Feedback and Modulatory Circuits in the Somatosensory Cortex"

Prof. Anthony Holtmaat, Department of Basic Neurosciences, University of Geneva (Switzerland)

Bio: Dr. Holtmaat is a full professor in the Department of Basic Neurosciences, where he holds the IRP Chair Alain Rossier, and co-directs the Lemanic Neuroscience Doctoral School of the University of Geneva. He is a molecular and cellular neuroscientist, specialising in neuronal synaptic circuits. His lab studies the mechanisms by which sensory input and learning change synapses in cortical circuits. His work has provided conceptual frameworks for the underpinnings of cortical plasticity, which may provide handles for modulating cortical function in various disorders.

Abstract: My lab has a longstanding interest in the anatomy and function of neocortical circuits, and in how these circuits are shaped by experience and learning. In particular, we focus on the interaction between long-range pathways that provide higher-order feedback and lower-order feedforward inputs to cortical pyramidal neurons. I will present recent work showing that interhemispheric sensory integration relies on slow forms of inhibition mediated by neurogliaform cells, which are selectively recruited by callosal inputs to modulate pyramidal neuron activity and sensory perception. I will also discuss correlative light and electron microscopy studies of higher-order thalamocortical, corticocortical, and neuromodulatory axons in primary somatosensory cortex, revealing distinctive morphological features.

Fecha y hora: viernes, 6 marzo, 15.30 horas

Lugar: Seminario 4