Neural Mechanisms of Sensory Processing

Dr. Ángel Núñez Molina

Extra- and intracellular recordings in anesthetized animals.

Anatomical studies.

Optogenetic techniques

Personal

Ángel Núñez, Ph.D.
angel.nunez@uam.es
Irene Chaves-Coira, Ph.D.
irene.chaves@uam.es
Eduardo Malmierca, MD, Ph.D.
Jonathan Zegarra Valdivia

Past Lab Members, current employment

Thesis Advisor (last 5 years)

  • Neurotrophic uncoupling of IGF-1 in Alzheimer’s disease: translation into early diagnosis and involvement of lifestyle risk factors D. Ángel Trueba Sáiz. Fac. Medicina, Univ. Autónoma de Madrid. Codirigida con el Dr. Ignacio Torres Alemán. Sobresaliente Cum Laude, Febrero 2015.
  • Neurotrophic uncoupling of IGF-1 in Alzheimer’s disease: translation into early diagnosis and involvement of lifestyle risk factors. D. Ángel Trueba Sáiz. Fac. Medicina, Univ. Autónoma de Madrid. Codirigida con el Dr. Ignacio Torres Alemán. Febrero 2015.
  • Synaptic Plasticity and Sensory Information Processing through the Thalamus and the Cortex of the Rodent Barrel Field. Dña. Natali Barros Zulaica. Fac. Medicina, Univ. Autónoma de Madrid. Codirigida con el Prof. Alessandro Villa (Université de Lausanne, Suiza). Junio 2017.
  • Procesamiento de la información táctil: La corteza prefrontal medial como centro de integración sensorial. D. Jesús María Martín Cortecero. Fac. Medicina, Univ. Autónoma de Madrid. Julio 2017.
  • Basal forebrain-cortical pathways. An anatomical and physiological study in rodents. Implications in Alzheimer Dissease model in transgenic mice. Dña. Irene Chaves Coira. Fac. Medicina, Univ. Autónoma de Madrid. Septiembre 2017.
  • Registro electroencefalográfico de la actividad ictal en un modelo animal de ratones transgénicos APP/PS1 y en pacientes con enfermedad de Alzheimer. Dña. Karen Reyes Marín. Fac. Medicina, Univ. Autónoma de Madrid. Septiembre 2017.

Fundings (last 5 years)

 - Importancia del circuito cortico-prosencéfalo basal en el procesamiento de la información somatosensorial en la rata. Participación en los procesos de atención. Ministerio de Economía y Competitividad (BFU2012-36107). (2013-2015).

El sistema IGF-I/orexina/acetilcolina como nexo de unión entre co-morbilidad psiquiátrica y deterioro cognitivo en la enfermedad de Alzheimer. Ministerio de Economía y Competitividad (SAF2016-76462 AEI/FEDER). (2016-2019; 145.200€). Investigador Principal. Proyecto Coordinado con Prof. Ignacio Torres-Alemán (CSIC). CEI72 1286-A156; Proex: 189/16.

Publicaciones 5 años

Barros-Zulaica, N., and Núñez A. (2015). Synaptic Plasticity in the Somatosensory Cortex. Neurotransmitter 2: e588. doi: 10.14800/nt.588.

Castejón, C., Barros-Zulaica N., and Núñez A. (2016). Control of Somatosensory Cortical Processing by Thalamic Posterior Medial Nucleus: a New Role of Thalamus in Cortical Function. PlosOne 11(1):e0148169. doi: 10.1371/journal.pone.0148169.

Chaves-Coira, I., Barros-Zulaica N., Rodrigo-Angulo M. and Núñez A. (2016). Modulation of specific sensory cortical areas by segregated basal forebrain cholinergic neurons demonstrated by neuronal tracing and optogenetic stimulation in mice. Frontiers Neural Circuits 10:28. doi: 10.3389/fncir.2016.00028.

Martín-Cortcero, J. and Núñez A. (2016). Sensory responses in the medial prefrontal cortex of anesthetized rats. Implications for sensory processing. Neuroscience 339:109-123. doi: 10.1016/j.neuroscience.2016.09.045.

Castejón, C. and Núñez A.  (2016). Cortical Neural Computation by

Discrete Results Hypothesis. Frontiers Neural Circuits 10:81.

doi: 10.3389/fncir.2016.00081.

Diez-Garcia, A., Barros-Zulaica N., Núñez A., Buño W. and Fernandez de Sevilla D. (2017). Bidirectional Hebbian plasticity induced by low-frequency stimulation in basal dendrites of rat barrel cortex layer 5 pyramidal neurons. Frontiers Cellular Neuroscience. 11:8. doi.org/10.3389/fncel.2017.00008.

Stein, A.M., Munive, V., Fernandez, A. M., Núñez A. and Torres-Aleman I. (2017). Acute exercise does not modify brain activity and memory performance in APP/PS1 mice. PLoS ONE 12(5): e0178247.  doi.org/10.1371/journal.pone.0178247.

Robledinos-Antón, N, Rojo, A.I., Ferreiro, E., Núñez, A., Krause, K.H., Jaquet, V., Cuadrado, A. (2017). Transcription factor NRF2 controls the fate of neural stem cells in the subgranular zone of the hippocampus. Redox Biology 13:393-401. doi: 10.1016/j.redox.2017.06.010.

Rojo, A.I., Pajares, M., Rada, P., Núñez, A., Nevado-Holgado, A., Killik, R., Van Leuven, F., Ribe, E., Lovestone, S., Yamamoto, M., Cuadrado A. (2017). NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology. Redox Biology 13:444-451. doi: 10.1016/j.redox.2017.07.006.

Casas-Torremocha, D., Clasca, F. and Núñez, A. (2017). Plasticity of tactile responses mediated by the posterior medial thalamic nucleus in rat motor and somatosensory cortices. Frontiers Neural Circuits 11:69.

doi: 10.3389/fncir.2017.00069.

Reyes-Marín, K.E and Núñez, A. (2017). Seizure susceptibility in a transgenic animal model of Alzheimer’s disease and relationship with amiloid β plaques. Brain Research 1677: 93-100. doi: 10.1016/j.brainres.2017.09.026.

Chaves-Coira, I., Rodrigo-Angulo, M.L. and Núñez, A. (2018). Bilateral pathways from the basal forebrain to sensory cortices may contribute to synchronous sensory processing. Frontiers in Neuroanatomy 12:5. doi: 10.3389/fnana.2018.00005.

Chaves-Coira, I., Martín-Cortecero, J., Núñez, and Rodrigo-Angulo, M.L. (2018). Different basal forebrain nuclei display distinct projecting pathways and functional circuits to sensory primary and prefrontal cortices in the rat. Frontiers in Neuroaanatomy 12:69. doi: 10.3389/fnana.2018.00069.

Escudero, G. and Núñez, A. (2019). Medial prefrontal cortical modulation of whisker thalamic responses in anesthetized rats. Neuroscience 4522:30086-7. doi.org/10.1016/j.neuroscience.2019.01.059

Pereda-Pérez, I., Valencia, A., Baliyan, S., Núñez, A., Sanz-García, A., Zamora-Crespo, B., Rodríguez-Fernández, R., Esteban, J.A. and Venero, C. (2019). Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats. Neurobiology of Aging 78: 155-165.

doi.org/10.1016/j.neurobiolaging.2019.02.011

Casas-Torremocha, D., Prorrero, C., Rodriguez-Moreno, J., García-Amado, M., Lübke, J.H.R., Núñez, A. and Clasca, F. (2019). Posterior thalamic nucleus axons have different terminal structures and functional impact in the vibrissal motor and somatosensory cortices. Brain Structure and Function

doi.org/10.1007/s00429-019-01862-4.

Barros-Zulaica, N., Villa, A., and Núñez A. (2019). Response adaptation in barrel cortical neurons facilitates stimulus detection during rhythmic whisker stimulation in anesthetized mice. eNeuro 6(2) e0471-18.2019 1–15. doi.org/10.1523/ENEURO.0471-18.2019.

Zegarra-Valdivia, J.A., Santi, A., Fernandez de Sevilla, M.E., Núñez A. and Torres-Aleman I. (2019). Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities. Journal of Alzheimer’s Disease 69:979-987.

doi: 10.3233/JAD-190241.

Publications