Neural Mechanisms of Sensory Processing


Extra- and intracellular recordings in anesthetized animals.

Anatomical studies.

Optogenetic techniques


Chaves-Coira, Irene, Ph.D.

Malmierca, Eduardo, MD, Ph.D.

Nuñez, Angel, Ph.D.

Rodrigo-Angulo, Margarita, Ph.D.

Barros Zulaica, Natali

Castejon, Carlos

Chasves Coira, Irene

Escudero Pérez, Guillermo

Martín Cortecero, Jesús


  • 2016

Castejón, C., N. Barros-Zulaica, and A. Núñez (2016). Control of Somatosensory Cortical Processing by Thalamic Posterior Medial Nucleus: a New Role of Thalamus in Cortical Function. PlosOne 11(1):e0148169. doi: 10.1371/journal.pone.0148169.

Chaves-Coira, I., N. Barros-Zulaica, M. Rodrigo-Angulo and A. Nuñez (2016). Modulation of specific sensory cortical areas by segregated basal forebrain cholinergic neurons demonstrated by neuronal tracing and optogenetic stimulation in mice. Frontiers Neural Circuits 10:28. doi: 10.3389/fncir.2016.00028.

Martín-Cortcero, J. and A. Nuñez (2016). Sensory responses in the medial prefrontal cortex of anesthetized rats. Implications for sensory processing. Neuroscience 339:109-123. doi: 10.1016/j.neuroscience.2016.09.045.

Castejón, C. and A. Nuñez (2016). Cortical Neural Computation by Discrete Results Hypothesis. Frontiers Neural Circuits 10:81. doi: 10.3389/fncir.2016.00081.

  •  2015

Barros-Zulaica, N., A. Núñez (2015). Synaptic Plasticity in the Somatosensory Cortex. Neurotransmitter 2: e588. doi: 10.14800/nt.588.

  • 2014

Malmierca, E., I. Chaves-Coira, M. Rodrigo-Angulo, A. Núñez (2014). Corticofugal projections induce long-lasting effects on somatosensory responses in the trigeminal complex of the rat. Frontiers in Systems Neuroscience doi:10.3389/fnsys.2014.00100.

Martín-Cortecero, J., A. Núñez (2014) Cholinergic modulation of tactile response adaptation in the barrel cortex of rats. Brain Research 1591: 27-37 doi:10.1016/j.brainres.2014.10.002.

 Barros-Zulaica, N., C. Castejon, A. Núñez (2014). Frequency-specific response facilitation of supra and infragranular barrel cortical neurons depends on NMDA-receptor activation in rats. Neuroscience 281: 178-194.

Molina-León, A. and A. Núñez (2014). EEG Morphology and Spectral Analysis in Attention Deficit/ Hyperactivity Disorder. Effect of Methylphenidate Treatment. Journal of Sleep Disorders: Treatment & Care  4.

  • 2013

Trueba-Sáiz A, C. Cavada, A.M. Fernández, T. León, D.A. González, J. Fortea- Ormaechea, A. Lleó, T. Del Ser, A. Núñez, I. Torres-Alemán (2013).  Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice. Translational Psychiatry 3, e330; doi:10.1038/tp.2013.102.

Tortorella, S., M. Rodrigo-Angulo, A. Núñez, M. Garzon (2013). Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep- wakefulness cycle. Frontiers in Neuropharmacology doi: 10.3389/fnins.2013.00216.

  • 2012

Núñez, A. S. Dominguez, W. Buño, D. Fernández de Sevilla (2012). Cholinergic-mediated enhancement in barrel cortex layer V pyramidal neurons. Journal Neurophysiology 108: 1656–1668.

Navarrete, M., G. Perea, D. Fernández de Sevilla, M. Gómez-Gonzalo, A. Núñez, E. Martín, A. Araque (2012). Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. Plos Biology 10: 1-12.

Malmierca, E., Y.B. Martín, A. Núñez (2012). Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat. Neuroscience  221:115-24.



Thesis Advisor (last 5 years)

  • Neurotrophic uncoupling of IGF-1 in Alzheimer’s disease: translation into early diagnosis and involvement of lifestyle risk factors D. Ángel Trueba Sáiz. Fac. Medicina, Univ. Autónoma de Madrid. Codirigida con el Dr. Ignacio Torres Alemán. Sobresaliente Cum Laude, Febrero 2015.

Fundings (last 5 years)

- Modulación colinérgica del procesamiento de la información somatosensorial en la corteza cerebral de la rata. Ministerio de Científica y Tecnología (SAF2009-10339). (2010-2012).

- Estimulación epidural del área somatosensorial secundaria en el tratamiento del dolor intratable post-traumático y oncológico. Fundación Médica Mutua Madrileña (2012-2014).

 - Importancia del circuito cortico-prosencéfalo basal en el procesamiento de la información somatosensorial en la rata. Participación en los procesos de atención. Ministerio de Economía y Competitividad (BFU2012-36107). (2013-2015).